Polygala Caudata
By 4muskateers
06-09-08
Polygala can be found in an herbal extract called Ren Shen Yang Rong Tang (in Chinese) or Ninjn'yoeito (In Japanese). It took me a long time to figure that out! Below is more research on using this plant extract to re-myelinate damaged nerves. I've only been taking it for a week so I don't know if it actually works on humans yet. Stay tuned.....
1: J Neurosci Res. 2007 Apr;85(5):954-66.
Restoration of FcRgamma/Fyn signaling repairs central nervous system
demyelination.
Seiwa C, Yamamoto M, Tanaka K, Fukutake M, Ueki T, Takeda S, Sakai R, Ishige A,
Watanabe K, Akita M, Yagi T, Tanaka K, Asou H.
Department of Neuro-Glia Cell Biology, Tokyo Metropolitan Institute of
Gerontology, Tokyo, Japan.
Disruption of myelin causes severe neurological diseases. An understanding of the mechanisms that control myelination and remyelination is needed to develop therapeutic strategies for demyelinating diseases such as multiple sclerosis
(MS). Our previous finding indicating the critical involvement of the gamma chain of immunogloblin Fc receptors (FcRgamma) and Fyn signaling in oligodendrocyte differentiaion and myelination demands a fundamental revision of the strategies used for MS therapy, because antigen-antibody complexes in MS patients may induce
the direct dysregulation of myelination process as well as the inflammatory destruction of myelin sheath. Here we show that the FcRgamma/Fyn signaling cascade is critically involved in cuprizone-induced demyelination/remyelination,
with no lymphocytic response. The levels of phosphorylated myelin basic proteins (p-MBPs), especially the 21.5-kDa isoform, but not the levels of total MBPs, decreased markedly during demyelination induced by aging, cuprizone treatment, and double knockout of FcRgamma/Fyn genes. We also showed that the recovery from demyelination in cuprizone-treated and aged mice is achieved after administration of the herbal medicine Ninjin'yoeito, an effective therapy targeting the
FcRgamma/Fyn-Rho (Rac1)-MAPK (P38 MAPK)-p-MBPs signaling cascade. These results suggest that the restoration of FcRgamma/Fyn signaling represents a new approach for the treatment of demyelinating diseases.
1: J Neurosci Res. 2007 Apr;85(5):954-66.
Restoration of FcRgamma/Fyn signaling repairs central nervous system
demyelination.
Seiwa C, Yamamoto M, Tanaka K, Fukutake M, Ueki T, Takeda S, Sakai R, Ishige A,
Watanabe K, Akita M, Yagi T, Tanaka K, Asou H.
Department of Neuro-Glia Cell Biology, Tokyo Metropolitan Institute of
Gerontology, Tokyo, Japan.
Disruption of myelin causes severe neurological diseases. An understanding of the mechanisms that control myelination and remyelination is needed to develop therapeutic strategies for demyelinating diseases such as multiple sclerosis
(MS). Our previous finding indicating the critical involvement of the gamma chain of immunogloblin Fc receptors (FcRgamma) and Fyn signaling in oligodendrocyte differentiaion and myelination demands a fundamental revision of the strategies used for MS therapy, because antigen-antibody complexes in MS patients may induce
the direct dysregulation of myelination process as well as the inflammatory destruction of myelin sheath. Here we show that the FcRgamma/Fyn signaling cascade is critically involved in cuprizone-induced demyelination/remyelination,
with no lymphocytic response. The levels of phosphorylated myelin basic proteins (p-MBPs), especially the 21.5-kDa isoform, but not the levels of total MBPs, decreased markedly during demyelination induced by aging, cuprizone treatment, and double knockout of FcRgamma/Fyn genes. We also showed that the recovery from demyelination in cuprizone-treated and aged mice is achieved after administration of the herbal medicine Ninjin'yoeito, an effective therapy targeting the
FcRgamma/Fyn-Rho (Rac1)-MAPK (P38 MAPK)-p-MBPs signaling cascade. These results suggest that the restoration of FcRgamma/Fyn signaling represents a new approach for the treatment of demyelinating diseases.
Messages posted for this Topic
Really intersting....
By wktb
06-09-08
Where did you find out about this? Wow-five years until an RX is available---that is way too long!
~Kristin
~Kristin
searching
By 4muskateers
06-09-08
Frank is searching and searching for ways to regrow the myelin...I'll keep you posted...in the mean time search for yourself and see if this is what will work for you...A med that is waiting to be tried for the regrowth of myelin will be out in 5 yrs...can you wait for an Rx for 5 years or try what the chineese have use for centuries.
