Research at UNC Chapel Hill
By momo3auts
08-09-08
Clinical Research
How to use this page: This page describes all studies related to children. The
categories are Autism, Psychotic Disorders, Mood Disorders and Velocardiofacial Syndrome (VCFS).
Below are the names and brief descriptions of each study. If you see a study that
may apply to you, click on the link and get further details on the study and contact
formation.
Autism Studies
Functional MRI Evaluation of the Effect of Citalopram in Autism Spectrum Disorders
Individuals with high-functioning autism (males and females 10-55 years old) will be recruited for a study that will use harmless and non-invasive brain imaging (functional MRI) to investigate how citalopram (also known as Celexa(r)) helps to reduce symptoms of restricted interests and repetitive behaviors.
Ages: 10 - 55 years
Social Cognition and Interaction Training for Adolescents with High Functioning Autism (SCIT-A)
Teens diagnosed with High Functioning Autism and Asperger’s Syndrome (14-18 years old) will be recruited for a 12 – 16 week study to improve social skills through a group-based social cognitive intervention.
Ages: 14 - 18 years
A Longitudinal MRI Study of Brain Development in Autism
The goal of the current research project is to increase our understanding of
normal brain development and how the brain develops in children with autism and
developmental delay. This new information will provide clues about how brain
development may differ for individuals with autism and related disorders.
Ages: 18 months to 35 months
SOFIA Study
In this study we are trying to determine what the effects of taking Prozac (fluoxetine ODT) are on repetitive behaviors in children diagnosed with an autism spectrum disorder. Cure Autism Now/Autism Speaks have partnered with a pharmaceutical company in order to better determine what effects this medicine has on treating symptoms related to autism. The medicine is a quick dissolving tablet that disappears in seconds once placed on the tongue.
Ages: 5-17 years
This study has a placebo (control) group
Study medication and treatment will be provided at no cost
Emotional Response Study
This study looks at how the brain responds to emotionally charged pictures and also to social and nonsocial pictures by recording changes in emotional reflexes in people aged 10-29 with High Functioning Autism (HFA). The study visit takes 1-2 hours and participants receive $60. This study is in collaboration with Dr. Gabriel Dichter in the Department of Psychiatry at UNC.
If you have any questions, please contact our project coordinator Betty Rupp at 919-843-8123 or by email at brupp@email.unc.edu.
Ages: 10-29 years
PAIRS
In this study, we are trying to determine what the effects of taking aripirazole are
on children and adolescents diagnosed with autism spectrum disorder who have
maladaptive behaviors such as hyperactivity, irritability, aggression, or anxiety.
By treating children with aripriprazole, we hope to improve overall functioning for
our study participants.
If you think that your child might be eligible for this study or would like more
information, please call the ASPIRE research hotline at 1-800-708-0048.
Ages: 30 months - 17 years
Study medication and treatment will be provided free of charge
IMPACT: Improving Metabolic Parameters Of Antipsychotic Child Treatment
The purpose of this study is to evaluate the relative risks and benefits of two
approaches to the control of weight gain and other negative side effects in children
and adolescents on 2 nd generation antipsychotics (SGA):
• Healthy lifestyle instruction (nutritional and physical activity surveillance and advice) + continuation of current SGA;
• Add the diabetes drug, metformin + continuation of current SGA.
Ages: 10 - 17 years
PREVENT: Metformin Mitigation Of Atypical Antipsychotic-Induced Metabolic
Dysregulation In Adolescent Youths
The purpose of this study is to determine whether starting metformin in conjunction
with a second-generation antipsychotic (SGA) and providing information about healthy
eating and activity will prevent or reduce the amount of weight gain and the metabolic
changes typically seen with second-generation antipsychotic medication.
Ages: 10 - 17 years
Psychotic Disorders Studies:
IMPACT: Improving Metabolic Parameters Of Antipsychotic Child Treatment
The purpose of this study is to evaluate the relative risks and benefits of two
approaches to the control of weight gain and other negative side effects in children
and adolescents on 2nd generation antipsychotics (SGA):
• Healthy lifestyle instruction (nutritional and physical activity surveillance and advice) + continuation of current SGA;
• Add the diabetes drug, metformin + continuation of current SGA.
Ages: 10 - 17 years
PREVENT: Metformin Mitigation Of Atypical Antipsychotic-Induced Metabolic
Dysregulation In Adolescent Youths
The purpose of this study is to determine whether starting metformin in conjunction
with a second-generation antipsychotic (SGA) and providing information about healthy
eating and activity will prevent or reduce the amount of weight gain and the metabolic
changes typically seen with second-generation antipsychotic medication.
Ages: 10 - 17 years
Mood Disorders Studies:
COLT: Pediatric Pharmacokinetic and Tolerability Study of Lithium for the
Treatment of Pediatric Mania Followed by an Open Label Long Term Safety
Period, Discontinuation Phase, and Restabilizaiton Period
The purpose of this study is to learn about lithium in the treatment of pediatric
patients with bipolar I disorder. This medication was chosen for this study because
it has been shown to be useful in the treatment of bipolar disorder in adults.
Ages: 7 - 17 years
© UNC Department of Psychiatry. Designed by the Educational Technology Group. All Rights Reserved.
How to use this page: This page describes all studies related to children. The
categories are Autism, Psychotic Disorders, Mood Disorders and Velocardiofacial Syndrome (VCFS).
Below are the names and brief descriptions of each study. If you see a study that
may apply to you, click on the link and get further details on the study and contact
formation.
Autism Studies
Functional MRI Evaluation of the Effect of Citalopram in Autism Spectrum Disorders
Individuals with high-functioning autism (males and females 10-55 years old) will be recruited for a study that will use harmless and non-invasive brain imaging (functional MRI) to investigate how citalopram (also known as Celexa(r)) helps to reduce symptoms of restricted interests and repetitive behaviors.
Ages: 10 - 55 years
Social Cognition and Interaction Training for Adolescents with High Functioning Autism (SCIT-A)
Teens diagnosed with High Functioning Autism and Asperger’s Syndrome (14-18 years old) will be recruited for a 12 – 16 week study to improve social skills through a group-based social cognitive intervention.
Ages: 14 - 18 years
A Longitudinal MRI Study of Brain Development in Autism
The goal of the current research project is to increase our understanding of
normal brain development and how the brain develops in children with autism and
developmental delay. This new information will provide clues about how brain
development may differ for individuals with autism and related disorders.
Ages: 18 months to 35 months
SOFIA Study
In this study we are trying to determine what the effects of taking Prozac (fluoxetine ODT) are on repetitive behaviors in children diagnosed with an autism spectrum disorder. Cure Autism Now/Autism Speaks have partnered with a pharmaceutical company in order to better determine what effects this medicine has on treating symptoms related to autism. The medicine is a quick dissolving tablet that disappears in seconds once placed on the tongue.
Ages: 5-17 years
This study has a placebo (control) group
Study medication and treatment will be provided at no cost
Emotional Response Study
This study looks at how the brain responds to emotionally charged pictures and also to social and nonsocial pictures by recording changes in emotional reflexes in people aged 10-29 with High Functioning Autism (HFA). The study visit takes 1-2 hours and participants receive $60. This study is in collaboration with Dr. Gabriel Dichter in the Department of Psychiatry at UNC.
If you have any questions, please contact our project coordinator Betty Rupp at 919-843-8123 or by email at brupp@email.unc.edu.
Ages: 10-29 years
PAIRS
In this study, we are trying to determine what the effects of taking aripirazole are
on children and adolescents diagnosed with autism spectrum disorder who have
maladaptive behaviors such as hyperactivity, irritability, aggression, or anxiety.
By treating children with aripriprazole, we hope to improve overall functioning for
our study participants.
If you think that your child might be eligible for this study or would like more
information, please call the ASPIRE research hotline at 1-800-708-0048.
Ages: 30 months - 17 years
Study medication and treatment will be provided free of charge
IMPACT: Improving Metabolic Parameters Of Antipsychotic Child Treatment
The purpose of this study is to evaluate the relative risks and benefits of two
approaches to the control of weight gain and other negative side effects in children
and adolescents on 2 nd generation antipsychotics (SGA):
• Healthy lifestyle instruction (nutritional and physical activity surveillance and advice) + continuation of current SGA;
• Add the diabetes drug, metformin + continuation of current SGA.
Ages: 10 - 17 years
PREVENT: Metformin Mitigation Of Atypical Antipsychotic-Induced Metabolic
Dysregulation In Adolescent Youths
The purpose of this study is to determine whether starting metformin in conjunction
with a second-generation antipsychotic (SGA) and providing information about healthy
eating and activity will prevent or reduce the amount of weight gain and the metabolic
changes typically seen with second-generation antipsychotic medication.
Ages: 10 - 17 years
Psychotic Disorders Studies:
IMPACT: Improving Metabolic Parameters Of Antipsychotic Child Treatment
The purpose of this study is to evaluate the relative risks and benefits of two
approaches to the control of weight gain and other negative side effects in children
and adolescents on 2nd generation antipsychotics (SGA):
• Healthy lifestyle instruction (nutritional and physical activity surveillance and advice) + continuation of current SGA;
• Add the diabetes drug, metformin + continuation of current SGA.
Ages: 10 - 17 years
PREVENT: Metformin Mitigation Of Atypical Antipsychotic-Induced Metabolic
Dysregulation In Adolescent Youths
The purpose of this study is to determine whether starting metformin in conjunction
with a second-generation antipsychotic (SGA) and providing information about healthy
eating and activity will prevent or reduce the amount of weight gain and the metabolic
changes typically seen with second-generation antipsychotic medication.
Ages: 10 - 17 years
Mood Disorders Studies:
COLT: Pediatric Pharmacokinetic and Tolerability Study of Lithium for the
Treatment of Pediatric Mania Followed by an Open Label Long Term Safety
Period, Discontinuation Phase, and Restabilizaiton Period
The purpose of this study is to learn about lithium in the treatment of pediatric
patients with bipolar I disorder. This medication was chosen for this study because
it has been shown to be useful in the treatment of bipolar disorder in adults.
Ages: 7 - 17 years
© UNC Department of Psychiatry. Designed by the Educational Technology Group. All Rights Reserved.
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