Research involving large Middle Eastern families, sophisticated genetic analysis and groundbreaking neuroscience has implicated a half-dozen new genes in autism. More importantly, it strongly supports the emerging idea that autism stems from disruptions in the brain's ability to form new connections in response to experience consistent with autism's onset during the first year of life, when many of these connections are normally made.
Interestingly, not all the affected genes were actually deleted, but only prevented from turning on offering hope that therapies could be developed to reactivate the genes. The study, led by researchers at Children's Hospital Boston and members of the Boston-based Autism Consortium, is the cover article in the July 11 issue of Science.